Sfera Garcinia Gambogia 60caps Maximize

Sfera Garcinia Gambogia 60caps

Garcinia Gambogia is the perfect supplement to help assist in weight management without any side-effects.

More details

90 Caps

R 162.30

Garcinia Gambogia

INGREDIENTS:  one vegetarian capsule provides:

Garcinia Cambogia (60% extract)               500mg

 

Providing 300mg HCA (Hydroxy citric acid)

 

Other ingredients:  Cellulose vegi-capsule, vegetarian magnesium stearate

 

Disclaimer: All information contained on this website is for information only and should not be used to diagnose, prevent, treat or cure any disease, health or medical condition. The products (food supplements) are not intended to diagnose, prevent, treat or cure any health or medical condition. Do not exceed stated dose or use with prescribed medication unless advised by a doctor or medical practitioner. Do not take if pregnant or lactating. Keep out of reach of children. Consult doctor for all medical advice.


Technical information:

Also known as… BrindalBerry, HCA, Hydroxycitrate, Malabar Tamarind and Vrikshamla.  Do not confuse with Gamboge, Malabar Nut, Mangosteen or Tamarind.

Mechanism of action

The Garcinia fruit rind is theorized to interfere with lipogenesis (1).  The active ingredient HCA is believed to be a competitive inhibitor of ATP-citrate-lyase, the enzyme responsible for converting citrate into acetyl-coenzyme A (acetyl-CoA).  This conversion into acetyl-CoA occurs when the energy consumed exceeds the energy requirements of the body (2).

Other researchers thing that garcinia inhibits the supply of fatty acids without affecting adipose conversion.  Preliminary research suggests that garcinia inhibits the accumulation of lipid droplets in fat cells and thereby reduces lipid levels and decreased lipid accumulation in the liver (3).  The HCA found in garcinia is also theorized to improve exercise endurance by increasing lipid oxidation and decreasing carbohydrate utilization.(4)(4487).  Some research suggests that HCA might suppress appetite.

Other useful studies include:

WEIGHT LOSS- Research conducted on 90 obese subjects at Georgetown University in Washington concluded that at the end of 8 weeks, both body weight and body mass index (BMI) decreased by 5.4%, low-density lipoprotein and triglycerides levels were reduced by 12.9% and 6.9%, respectively, while high-density lipoprotein levels increased by 8.9%, serum leptin levels decreased by 38%, serotonin levels increased by 44.5% and urinary excretion of fat metabolites increased by 32-109%.  No significant adverse effects were observed and the results confirm that HCA reduces body weight and BMI, suppresses appetite, improves blood lipid profiles, and increases serum leptin and serotonin levels and increases fat oxidation more than placebo. (5)

EXERCISE PERFORMANCE - One study examined the effects of Hydroxycitrate (HCA) ingestion on fat oxidation during moderate intensity exercise in untrained men. Six subjects ingested 500 mg of HCA or a placebo for 5 days and did endurance exercise. Blood FFA concentrations were significantly increased and respiratory exchange ratio (RER) decreased by HCA ingestion. These results suggested short-term HCA ingestion increases fat oxidation in untrained men. A number of other studies suggest that even short-term administration of HCA enhances endurance performance with increasing fat oxidation, which spares glycogen utilization during moderate intensity exercise in athletes.(6)


Safety Concerns


Adverse Reactions

Orally, garcinia can cause nausea, GI discomfort, and headache (7).

Interactions with herbs and other dietary supplements

None known

Interactions with drugs

None known

Interactions with foods

None known

Interactions with lab tests

None known

Interactions with Diseases or Conditions

None known

 

Pregnancy and lactation – insufficient reliable information, avoid using.

Dosage and Administration

Take one 500mg capsule four times daily.


References

1.  JAMA 1998;280:1596-600.

2.  JAMA 1999;282:233-4; discussion 235. 

3.  Phytother Res 2001;15:172-3.

4.  Food Chem Toxicol 2004;42:1513-29.

5. Preuss HG, Garis RI, Bramble JD, Bagchi D, Bagchi M, Rao CV, Satyanarayana S. Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. Department of Physiology and Biophysics,GeorgetownUniversityMedicalCenter, Basic Science

6.  Cheema-Dhadli S, Harlperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem 1973;38:98–102.

7.  Food Chem Toxicol 2004;42:1513-29.

More useful studies:

Sullivan AC, Triscari J. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr 1977;30:767–76.

Sergio W. A natural food, Malabar Tamarind, may be effective in the treatment of obesity. Med Hypotheses 1988;27:39–40.

Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent. JAMA 1998;280:1596–600.

Seroy S. Response to JAMAHCAreport. Townsend Letter for Doctors and Patients Feb/Mar 1999:120–1 [letter/review].

Badmaev V, Majeed M, Conte AA. Garcinia cambogia for weight loss. JAMA 1999;282:233–4 [letter].

Lowenstein JM. Experiments with (-)hydroxycitrate. In: Burtley W, Kornberg HL, Quayle JR, eds. Essays in Cell Metabolism.New York: Wiley Interscience, 1970, 153–66.

Lim K, Ryu S, Suh H, Ishihara K, Fushiki T. (-)-Hydroxycitrate ingestion and endurance exercise performance. J Nutr Sci Vitaminol (Tokyo). 2005 Feb;51(1):1-7.

Tomita K, Okuhara Y, Shigematsu N, Suh H, Lim K. (-)-hydroxycitrate ingestion increases fat oxidation during moderate intensity exercise in untrained men. Biosci Biotechnol Biochem. 2003 Sep;67(9):1999-2001.

Lim K, Ryu S, Nho HS, Choi SK, Kwon T, Suh H, So J, Tomita K, Okuhara Y, Shigematsu N. (-)-Hydroxycitric acid ingestion increases fat utilization during exercise in untrained women. J Nutr Sci Vitaminol (Tokyo). 2003 Jun;49(3):163-7.